Open Competition RFA (WVCTSI and WVU Cancer Institute)

COMPLETE RFA

The goal of this Request for Applications (RFA) is to support clinical and translational pilot projects for mid-career cancer investigators, in order to generate preliminary data for external NIH applications, and with the ultimate goal of improving health in West Virginia and Appalachia.

NOTE: West Virginia University Cancer Institute (WVUCI) membership is required. The application form for membership can be found here.

LOI Deadline:                               November 5, 2018

Application Deadline:                 January 7, 2019

 

Applicants are encouraged to meet with the Investigator Development Manager prior to application submission.

Meghan Reeves, MPH                 mreeves1@hsc.wvu.edu               304-293-6581

 

Required Letter of Intent (LOI)

To better serve those applying for West Virginia Clinical and Translational Science Institute pilot project funding, Letters of Intent (LOI) will be required from interested Principal Investigators.

Letters of Intent, and subsequent proposals, submitted in response to this RFA MUST focus on cancer, including:

  • Cancer clinical research
  • Cancer prevention and early detection research
  • Laboratory based cancer research

Translational research efforts that bridge at least two of these three areas of inquiry are especially requested.

The LOI should follow the template found here.

LOIs are required and must be submitted via iLab as a single PDF document on or before the deadline. The LOIs will be used to facilitate planning for the proper reviewers needed for the evaluation of the full proposals. In addition, the LOIs will be used to provide feedback to further strengthen the full proposal applications. Some investigators will be asked to meet with Pilot Projects Program Senior Scientific Advisors to review their LOI and provide specific feedback regarding their submitted protocol. Following review of submitted LOIs, all PIs will receive an e-mail notifying them that their LOI has been reviewed, and including any additional feedback from the LOI reviewers.

Investigators whose projects are consistent with our mission and the scope of this RFA will be invited to submit full proposals. Unsolicited full proposals from PIs who do not submit an LOI will NOT be reviewed nor considered for funding.

Budget

For this funding cycle, the budget is limited to a maximum of $50,000 in total direct costs for up to twenty-four (24) months. The budget is not intended to provide salary support.

Compliance Requirements for a Full Proposal

PIs submitting a full proposal in response to this RFA must include CITI certification for investigators conducting research or collecting outcomes with human and/or animal subjects as well as documentation of IRB and/or IACUC protocol submission. Documentation for these requirements should be included in the Appendix of the application. IRB/IACUC approval are not required prior to application submission deadline but must be completed within 60 days of notice of grant award. Note that all WVCTSI Pilot awards require final NIH approval before funds can be released and official proof of IRB/IACUC approval is required to obtain NIH approval. Therefore no project can start nor funds be released without proper compliance documentation.

Past Pilot Funded Principal Investigators

Any Principal Investigator submitting a full proposal that has received past WVCTSI pilot grant funding (anytime), or INBRE pilot grant funding (anytime) must include the following in their appendix:

  1. A paragraph that, in layman’s terms, clearly describes how this proposal differs from past funded projects. Please describe if this is a new project, or an extension of past funded projects.
  2. Please list any and all publications that resulted from past funded pilot grants as well document any external grant submissions, and results of external grant submissions (funded, scored, not funded). If there are other items that demonstrate the productivity of past WVCTSI or INBRE funded pilot grants please describe them as well.

* Note: Significant prior WVCTSI, INBRE, COBRE, and/or current NIH funding will likely result in low priority during the reviewing process unless the new proposal is radically different from previous projects. The WVCTSI Pilot Core Program’s mission is to support the growth of investigators in order to promote high-quality research resulting in increased team science, dissemination of finding, and extramural funding success. As such, priority is typically given to promising researchers in early stages of their career and who haven’t yet secured significant other funding sources. We respect the time and effort that all applicants dedicate to their proposals, and welcome inquiry about eligibility prior to any formal submission.  

Eligibility Information

  • Principal Investigator (PI) must hold a faculty appointment or equivalent at the time the award is announced. For the purposes of this RFA, these are individuals who can independently apply for federal or non- federal investigator-initiated, peer-reviewed Research Project Grants (RPG). Individuals holding postdoctoral fellowships or other positions that lack independent status are not eligible to lead pilot projects.
  • The PI must be a WVUCI member, although co-Investigators may include WVU faculty outside of the WVUCI and/or researchers with appointments at other institutions. Note that WVUCI membership is open to all WVU faculty members, Health Sciences Center affiliated schools, and WVU colleges.
  • The present RFA is designed for mid-level faculty members as defined by having had a faculty appointment at WVU or another research institution for at least 5 years (no maximum limit).

    Investigators who do not meet those requirements are NOT eligible for this funding opportunity. If interested in WVCTSI funding, these individuals can learn more about other opportunities on the WVCTSI website.

Restrictions

  • Faculty named in the WVCTSI organization (i.e. program chairs and key personnel) are restricted from serving as PI on WVCTSI pilot grants, as well as prohibited from having funds directed to their labs or programs. However, such individuals may be included on pilot grants in supportive roles such as Co-Investigators, mentors, and consultants.
  • The Project lead for Pilot projects may not concurrently have funding from other IDeA Program award mechanisms (e.g. INBRE, COBRE).
  • Pilot projects may not overlap with other ongoing WVCTSI-funded projects.

* Note: Significant prior WVCTSI, INBRE, COBRE, and/or current NIH funding will likely result in low priority during the reviewing process unless the new proposal is radically different from previous projects. The WVCTSI Pilot Core Program’s mission is to support the growth of investigators in order to promote high-quality research resulting in increased team science, dissemination of finding, and extramural funding success. As such, priority is typically given to promising researchers in early stages of their career and who haven’t yet secured significant other funding sources. We respect the time and effort that all applicants dedicate to their proposals, and welcome inquiry about eligibility prior to any formal submission.  

Resubmissions

Per NIH guidelines, only one (1) resubmission is allowed for any given proposal. If you are planning on completing a resubmission, please contact the WVCTSI team prior to re-submitting your application.

Note: All documents described below require the NIH PHS 398 Forms found here.

 

COMPLETE RFA

LETTER OF INTENT (LOI)

MENTORSHIP AGREEMENT PLAN

PHS 398 Forms

Submission Checklist

Clinical Trials Template