Open Competition RFA


The goal of this Request for Applications (RFA) is to support clinical and translational pilot projects relevant to improving health in West Virginia and Appalachia.

LOI Deadline:                               October 17th, 2017

Application Deadline:                 November 28th, 2017


Applicants are encouraged to meet with the Investigator Development Manager prior to application submission.

Meghan Reeves, MPH                      304-293-6581


Required Letter of Intent (LOI)

To better serve those applying for West Virginia Clinical and Translational Science Institute pilot project funding, Letters of Intent (LOI) will be required from interested Co-Project Leaders (Co-PLs)/Co-Principal Investigators (Co-PIs). The proposed collaborative projects should address health care needs of West Virginia. Examples include, but are not limited to, the following health care issues:

  • Addiction and Resultant Emerging Epidemics (hepatitis C)
  • Cancer
  • Cardiovascular Disease
  • Chronic Lung Disease
  • Neuroscience


The LOI should follow the template and can be found here.

LOIs are required and must be submitted via email as a single PDF document on or before the deadline. Applications should be emailed to Meghan Reeves via email  The LOIs will be used to facilitate planning for the proper reviewers needed for the evaluation of the full proposals. In addition, the LOIs will be used to provide feedback to further strengthen the full proposal application. Some investigators will be asked to meet with Pilot Projects Program Senior Scientific Advisors to review their LOI and provide specific feedback regarding their submitted protocol.

All Co-PIs will receive an e-mail notification after the LOI has been reviewed as well as any additional feedback from the LOI reviewers. Unsolicited full proposals from Co-PIs that do not submit a LOI by the 10/17/17 deadline will not be reviewed nor considered for funding.


For this funding cycle, the budget is limited to a maximum of $50,000 in total direct costs for a twelve (12) months.

Compliance Requirements for a Full Proposal

PIs submitting a full proposal in response to this RFA must include CITI certification for investigators conducting research or collecting outcomes with human subjects as well as documentation of IRB protocol submission and/or IACUC protocol submission. Documentation for these requirements should be included in the Appendix of the application. IRB and IACUC approval are not required prior to application submission deadline but must be completed within 30 days of notice of grant award.

Past Pilot Funded Principal Investigators

Any Principal Investigator submitting a full proposal that has received past WVCTSI pilot grant funding (anytime), or INBRE pilot grant funding (anytime) must include the following in their appendix:

1.    A paragraph that in layman’s terms describes how this proposal differs from past funded projects. Please describe if this is a new project, or an extension of past funded projects.

2.    Please list any and all publications that resulted from past funded pilot grants as well document any external grant submissions, and results of external grant submissions (funded, scored, not funded). If there are other items that demonstrate the productivity of past WVCTSI or INBRE funded pilot grants please describe them as well.

Eligibility Information

  • Principal Investigator (PI) must hold a faculty appointment or equivalent at the time the award is announced. For the purposes of this RFA, these are individuals who can independently apply for federal or non- federal investigator-initiated, peer-reviewed Research Project Grants (RPG). Individuals holding postdoctoral fellowships or other positions that lack independent status are not eligible to lead pilot projects.
  • PI’s at Marshall University must hold a faculty appointment in the School of Medicine.
  • All Early Stage Investigator (ESI) PIs must complete the one page attachment with signature from proposed mentor. Mentorship Agreement Plan can be found here. Early Stage Investigator(ESI) Principal Investigators, as defined by the NIH as a new investigator who has completed his or her terminal research degree or medical or other professional residency—whichever date is later—within the past 10 years and has not yet been awarded a substantial, competing NIH research grant.


  • The Project lead for Pilot projects may not concurrently have funding from other IDeA Program award mechanisms (e.g. INBRE, COBRE).
  • Pilot projects may not overlap with other ongoing WVCTSI-funded projects