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Administrative: The Administrative core manages all central support provided by the institute including faculty recruitment, investigator development, communications, and research administration/ financial management.

  • Coordinates all cores with twice monthly management meetings.
  • WVCTSI has recruited 26 magnet clinical and translational faculty and junior investigators.


Biomedical Informatics Resources: The BMIR program supports the development of robust clinical and translational research projects through the utilization of unique clinical data.

  • Integrated Data Repository with over 2 million lives allows for easier access to data including demographics, medications, procedures performed, diagnoses, and geography.
  • New TriNetX partnership allows for deeper data searches and facilitates clinical trial recruitment.


Clinical Trials Research Unit: The CTRU provides investigators with the services and expertise necessary to conduct clinical trials and guide participants through the clinical trial process.

  • The CTRU has greatly expanded the number of non-cancer clinical trials.
  • There are currently 137 active clinical trials, which have included 900 participants in the last year.


Community Engagement and Outreach: The CEO core leverages partnerships across the state to conduct community engaged research that benefits the people of Appalachia.

  • Created a statewide WV Practice-Based Research Network (PBRN) that includes 73 sites that stimulate patient-oriented community research.
  • Extension for Community Healthcare Outcomes (ECHO) is providing unprecedented rural access to specialized hepatitis-C treatment.


Professional Development (Clinical Research Education, Mentoring, & Career Development): The CREMCD core provides educational programs that create trained health professionals and researchers who will be competitive in securing external funding for research in WVCTSI’s priority health areas.

  • Over 1,400 people have participated in educational opportunities sponsored by WVCTSI. 
  • 4 educational degrees and certificates including a certificate, M.S., and Ph.D., in Clinical and Translational Science, as well as a certificate in Applied Biostatistics.


Clinical Research Design, Epidemiology, and Biostatistics: The CRDEB program provides clinical and translational researchers across the state with the biostatistical and epidemiologic expertise essential to addressing the health disparities among Appalachian patients.

  • CRDEB has created statewide access to analytical expertise in study design and analysis.
  • The variety of biostatistical and epidemiologic support offered has been utilized by over 300 unique investigators at 10 different schools and colleges. These services have led to the successful authorship of 131 peer-reviewed manuscripts.


Ethics, Regulatory Knowledge and Support: The ERKS core develops effective coordination measures that enhance the ethical conduct of research and ensure the respect for participant autonomy and wellbeing.

  • WVCTSI has created IRB reciprocity among all partner sites.
  • Time from IRB submission to approval has been cut in half.


Tracking, Evaluation and Quality Improvement: The TEQUIP program analyzes data to ensure all parts of WVCTSI are effectively accomplishing their missions to create a healthier Appalachia.

  • Engages WVCTSI and partner leadership in quarterly evaluations meetings to provide continuous program improvement.
  • Investigator Tracking and Support System captures data in real-time, leading to faster quality improvements.


Clinical and Translational Pilot Grants Program: The Pilot Grants program provides a mechanism for soliciting and awarding clinical, translational, and community engagement projects, from concept to competitiveness for external funding.

  • Established a program that continues to grow with an additional $1 million external funding received for years 4-5.
  • 77 projects addressing WVCTSI health priority areas have been funded to date.
  • Streamlined review system has reduced time from proposal submission to release of funding by 43 percent.